This training activity will be interdisciplinary and will concern the fields of chemistry, physics, materials, biology and medicine.
Axis 1 : Chemistry/materials
- What about reproducibility, GMP standards and scale-up of controlled nanoparticle and nanohybrid production. Which synthesis methods should be preferred and which methods of analysis should be used to scale up to industrial standards?
- Which compositions should be favored or avoided to facilitate obtaining the necessary authorizations to start clinical trials or commercialize?
Axis 2 : Physical properties/biology
- How to control the intrinsic properties of nanoparticles in vitro and in vivo (radiotherapy, photodynamic therapy, hyperthermia ...)?
- Development of multimodal nanoplateforms for medical imaging (MRI / PET, MRI / OI etc.) and theranostic nanomedicines, the challenges of tomorrow.
- Nanoscale characterizations of nanoparticle / protein interactions (SPR, AFM etc.).
Axis 3 : Chemistry/biology
- What parameters should be controlled to control the different forms of nanoparticle toxicity (cytotoxicity, oxidative stress, genotoxicity, carcinogenicity: implementation and referencing of adapted biotests)?
- Which parameters are required to control the biodistribution and clearance of nanoparticles?
- Which formulations and modes of administration should be preferred or avoided to facilitate obtaining the necessary authorizations to start clinical trials or commercialize?
Axis 4 : Biology/Chemistry
- Role and use of biological nanovesicles for vectorization of drugs;
- Importance of nanoparticle / protein interactions (protein corona).
